Biotransformation & Panchakarma: A Scientific Analysis of Metabolic Reset After Shodhana Therapies
Abstract
Biotransformation represents the body's ability to convert endogenous and exogenous substances
into forms that can be metabolized, utilized, or eliminated. Ayurveda describes this process
through the concepts of Agni, Ama, and Srotas, with Shodhana (Panchakarma) therapies acting as
the primary means to restore metabolic balance. Modern research now recognizes the capacity of
detoxification therapies to regulate inflammatory biomarkers, enhance gut microbiome diversity,
and modify metabolic pathways. This review aims to correlate Ayurvedic principles of Shodhana
with contemporary biochemical mechanisms of biotransformation, highlighting Panchakarma’s
influence on detoxification, gut health, mitochondrial activity, hormonal balance, and systemic
homeostasis
Keywords
Panchakarma, Biotransformation, Shodhana, Agni, Ama, Detoxification, Gut Microbiome, Virechana, Vamana, Basti, Metabolic Reset.