Abstract

Biotransformation represents the body's ability to convert endogenous and exogenous substances into forms that can be metabolized, utilized, or eliminated. Ayurveda describes this process through the concepts of Agni, Ama, and Srotas, with Shodhana (Panchakarma) therapies acting as the primary means to restore metabolic balance. Modern research now recognizes the capacity of detoxification therapies to regulate inflammatory biomarkers, enhance gut microbiome diversity, and modify metabolic pathways. This review aims to correlate Ayurvedic principles of Shodhana with contemporary biochemical mechanisms of biotransformation, highlighting Panchakarma’s influence on detoxification, gut health, mitochondrial activity, hormonal balance, and systemic homeostasis