Abstract

Background:Krutrima Visha (artificial or concocted poison) is described in Ayurveda as a toxic substance prepared by combining different poisonous and nonpoisonous materials. Mustadi Yoga, described in Bharat Bhaishajya Ratnavali Part IV, is a simple but potent formulation indicated for the rapid management of severe artificial poisoning. It consists of Musta (Cyperus rotundus), Tandulodaka (ricewash water), and Ghrita (ghee). Objective: To review the classical references, pharmacological properties, probable mode of action, and therapeutic significance of MustadiYoga in the management of KrutrimaVisha. Methods: A narrative review was conducted using classical Ayurvedic texts, published literature, pharmacognostic studies, and contemporary scientific evidence on the ingredients of MustadiYoga. Results:Musta possesses Deepana, Pachana, Vishaghna, Tridosha-shamaka, and antioxidant activities. Tandulodaka acts as an Anupana, enhancing drug absorption while maintaining hydration. Ghrita serves as a Yogavahi, facilitating drug delivery, reducing toxicity, and protecting body tissues. Together, these ingredients provide detoxifying, anti-inflammatory, antioxidant, gastroprotective, and hepatoprotective effects that support the management of artificial poisoning. Conclusion:Mustadi Yoga represents a classical Ayurvedic antidotal formulation with promising therapeutic potential in KrutrimaVisha. Although traditional evidence strongly supports its use, systematic experimental and clinical studies are needed to establish its efficacy and safety according to modern scientific standards.