Abstract

In India post operative anorectal wound remains a major problem following surgical procedures for common benign anorectal illness such as anal fissure, hemorrhoids, and fistula in ano. About 20-25% of surgeries land up into consequences such as delayed or non healing wounds leading to significant morbidity [6,8]. Symptoms of persistent pain, infection, abscess development, anal stricture, and even fecal incontinence, extending recovery time and lowering of quality of life due to poor wound healing. [5,6,8]. As the wound is in constant contact with fecal matter and water, there are very high chances of infection, and failure of modern wound care can be seen. Wound healing consists of three phases: inflammation, proliferation and remodeling. Any interruption in these phases will cause wounds to heal slowly or not at all, as seen in chronic granulation tissue, discharge and delayed epithelialization. And these conditions worsens the wound and such unhealed wounds raise healthcare expenses and increase chances of infection [5,6]. In ayurvedic literature Manjistha (Rubia cordifolia) is known for its anti-inflammatory, antioxidant, and antibacterial properties. Which helps in granulation and healing of tissue [1,3,7]. Ghrita being shita virya and having rich content of fatty acids, phospholipids and fat soluble vitamins (A, D, E and K) will provide moist and unctuous environment, minimize irritation and improve tissue regeneration. [2,4]. By combining both the drugs and using this formulation in post operative anorectal wounds can give promising results in wound healing. As the rate of morbidity and infection in post operative anorectal wounds are more there is a need to find adjuvant treatment methods that can speed up tissue healing, reduce inflammation and enhance postoperative outcomes. Hence, the current study is undertaken to investigate the efficacy of local application of manjistha ghrita in post operative anorectal wounds.