Abstract

Background: In Ayurveda, Grahani is considered an important site associated with Agni and plays a crucial role in digestion, absorption, and maintenance of systemic health. Impairment of Agni and disturbance of Grahani function may lead to improper digestion and altered metabolic processes. In contemporary medicine, gut health encompasses the functional integrity of the gastrointestinal tract, including digestion, absorption, intestinal barrier function, and interaction with the gut microbiota. Increasing evidence suggests that disturbances in gut function and metabolic regulation may contribute to obesity. Sthoulya, described in Ayurveda as a disorder of excessive accumulation of Meda, can therefore be studied in relation to disturbances in gastrointestinal and metabolic health. Aim: To explore the conceptual and clinical relationship between Grahani, gut health, and Sthoulya (obesity). Objectives: To study the Ayurvedic concepts of Grahani, Agni, and Sthoulya; to assess selected clinical parameters related to gut health and obesity; and to evaluate the possible association between Grahani dysfunction and features of Sthoulya. Methodology: A conceptual review of classical Ayurvedic literature and relevant contemporary scientific literature will be undertaken. Clinically relevant parameters reflecting digestive function, bowel habits, appetite, metabolic status, anthropometric measurements, and other indicators of gut health will be assessed in individuals with Sthoulya. The findings will be analysed to identify possible interrelationships between gastrointestinal function and obesity. Conclusion: Understanding the relationship between Grahani and gut health may provide a broader Ayurvedic perspective on the development and management of Sthoulya. Integrating Ayurvedic concepts with contemporary understanding of gut–metabolic health may contribute to a more comprehensive approach to obesity prevention and management.