Abstract

Arśa (piles/hemorrhoids) is a common anorectal disorder described extensively in Ayurvedic classics. Yogaratnakara recommends Tiladi Modaka as a therapeutic formulation for Arśa, yet systematic academic evaluation integrating classical rationale and modern research design remains limited. Objective: To critically review the classical basis, pharmacological rationale, and contemporary evidence for Tiladi Modaka in Arśa, and to propose a clinical research methodology. Methods: Classical references from Yogaratnakara and allied Ayurvedic texts were reviewed. Available modern pharmacological and clinical literature on Tiladi Modaka and its constituent drugs was synthesized. A prospective randomized pilot clinical trial protocol is proposed, including standard operating procedures (SOPs) for drug preparation and quality control. Results: Classical texts indicate Tiladi Modaka as Arśaghna through doṣa-śamana, śothahara, raktastambhana, and vranaropaṇa actions. Modern studies on individual constituents suggest anti-inflammatory, venotonic, wound-healing, antimicrobial, and laxative effects. Hypothetical pilot data presentation demonstrates potential reductions in pain, bleeding, discharge, and pile mass size.