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Authors / Members: Dr. Nikhil Gurav¹*, Dr. Vandana Wadhavane², Harsh Pravin Singh³, Raj Kailas Jaiswal⁴

Abstract: The management of localized inflammation (Shotha) and pain (Shoola) constitutes a significant portion of general medical practice. While contemporary medicine largely relies on NSAIDs and topical analgesics, the Ayurvedic pharmacopeia offers a range of transdermal applications known as Lepa. This review critically examines the formulation Panchakoladi Lepa, a compound cited in the Charaka Samhita comprising five specific pungent herbs. The paper analyzes the rationale behind this formulation, its putative mechanism of action regarding Kapha-Vata stagnation, and the clinical precautions required due to its vesicant properties. We posit that Panchakola acts not merely as a counter-irritant, but as a localized metabolic stimulant (Agni enhancer) capable of penetrating deep tissue barriers.

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