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Authors / Members: Dr. Shoeb Ahmed Riyazuddin, Dr. Nilesh Suresh Thorat, Dr. Dattatray Govind Parde

Abstract: Acharya charak described Sannipatodara as one of the type of udara, belongs to ashtomahagada, so it's difficult to cure. Udara Samprapti starts from defective digestion strength i. e. Agnidosha & causes malavruddhi & its accumulation. Increase in waste products and its stagnation are the reasons for the disease like Udara, Suppression of Agni & continuation of hetu sevana leads to Ama production & its accumulations, it vitiates prana, agni & apana due to which, there is obstruction to upward & downward channel of circulation. Overall, it causes vitiation & excessive provocation of vayu. Considering, its chronicity & severity due to excessive consumption of hetus, excessive accumulation of mala & toxins, the disease becomes irreversible. When Vata dosha becomes dominant, it disrupts overall body metabolism, making the patient susceptible to complications such as hepatic failure, hepato-renal syndrome, muscle wasting, hyperammonemia, and encephalopathy.. The pathogenesis of hepatic encephlopathy is multi-factorial & ammonia is considered as an important risk factor. As per Modern science, elevation in Blood Ammonia causes hepatic encephalopathy ammonia reaches the systemic circulation & accmulates in the central nervous system, to combact this chain of pathogenesis, we have selected "Shahastravedhi Tarun Sneha." Alcohol is direct hepato-toxic and will develope alcoholic hepatitis & further it will progress to liver cirrhosis. As the disease becomes advanced, serious complications of cirrhosis occurs. In liver cirrhosis, gut derived neuro-toxins that are not removed by the liver,because of vascular shunting and decrease hepatic mass gets to the brain. Ammonia is produced during normal protein metabolism in the colon. liver & striated muscles plays a major role in de-toxification of ammonia. Patients with advanced liver disease typically have significant muscle wasting & muscle wasting is common occurance in liver cirrhosis due to dominance of Vayu.Probable mode of action of Hingu misrit Erand sneh is described in current paper

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